Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …

Doxorubicin (DOX), a commonly used antitumor agent, is often accompanied by its dosage-
dependent cardiotoxicity, which incorporates ferroptosis in its pathogenesis. Protein arginine …

PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …

Nrf2 is a major transcription factor that significantly regulates—directly or indirectly—more
than 2000 genes. While many of these genes are involved in maintaining redox balance …

Klotho protein secreted in the blood could act as a hormone to regulate various target
organs and have a protective effect on the cardiovascular system. Numerous studies had …

Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress
and is a perspective target for oxidative stress-associated diseases. Under normal …

Protein arginine methyltransferases (PRMTs) catalyze protein arginine methylation and are
linked to carcinogenesis and metastasis. Some members of PRMTs have been found to …

Steroid receptors (SRs) are members of the nuclear hormonal receptor family, many of
which are transcription factors regulated by ligand binding. SRs regulate various human …

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) caused COVID‐19
epidemic is worsening. Binding of the Spike1 protein of SARS‐CoV‐2 with the angiotensin …