The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …

High-resolution X-ray crystal structures determined in the past six years dramatically
influence our view of ligand-induced activation of the epidermal growth factor receptor …

The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of
biological processes from neuronal development to breast cancer. New information …

Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …

Structural studies have shown that ligand-induced epidermal growth factor receptor (EGFR)
dimerization involves major domain rearrangements that expose a critical dimerization arm …

Structural studies have provided important new insights into how ligand binding promotes
homodimerization and activation of the EGF receptor and the other members of the ErbB …

The epidermal growth factor receptor (EGFR) is a member of the erbB tyrosine kinase family
of receptors. For many years it has been believed that receptor activation occurs via a …

Both the epidermal growth factor receptor (EGFR) and the insulin-like growth factor-1
receptor (IGF-1R) can contribute to tumor development and-progression through their effects …

Scatchard analysis of the binding of EGF to its receptor yields concave up plots that indicate
the presence of two classes of binding sites. However, how two independent classes of sites …

Research on the epidermal growth factor (EGF) family and the family of receptors (EGFR)
has progressed rapidly in recent times. New crystal structures of the ectodomains with …