Metabolic diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular
disease, and liver disease, have become increasingly prevalent around the world. As an …

Precision diabetes medicine (PDM) aims to reduce errors in prevention programmes,
diagnosis thresholds, prognosis prediction and treatment strategies. However, its …

The methyltransferase N6AMT1 has been associated with the progression of different
pathological conditions, such as tumours and neurological malfunctions, but the underlying …

This investigation explores the potential of plasma lipidomic signatures for aiding in the
diagnosis of Multiple Sclerosis (MS) and evaluating the clinical course and disease activity …

Aims/hypothesis People with type 2 diabetes are heterogeneous in their disease trajectory,
with some progressing more quickly to insulin initiation than others. Although classical …

Multiomics analyses have identified multiple potential biomarkers of the incidence and
prevalence of complex diseases. However, it is not known which type of biomarker is optimal …

Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation
of diverse origin. The long-standing paradigm that foam cells are cholesterol-laden derives …

Introduction Type 2 diabetes (T2D) onset, progression and outcomes differ substantially
between individuals. Multi-omics analyses may allow a deeper understanding of these …

Metabolomics, with its wealth of data, offers a valuable avenue for enhancing predictions
and decision-making in diabetes. This observational study aimed to leverage machine …

Obesity is considered by many as a lifestyle choice rather than a chronic progressive
disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity …