Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections
and malignancies. NK cells express a variety of inhibitory and activating receptors that …

A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …

The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Recent studies demonstrate that natural killer (NK) cells have adaptive immune features.
Here, we investigated the role of the costimulatory molecule DNAM-1 in the differentiation of …

Abstract The role of Natural Killer cells in host defense against infections as well as in
tumour surveillance has been widely appreciated for a number of years. Upon recognition of …

Natural killer (NK) cells represent key innate immune cells that restrain viral infection and
malignant transformation and help mount an adaptive immune response. To perform such …

NKG2D plays a major role in controlling immune responses through the regulation of natural
killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct …

Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire
mutations that impact viral growth. These laboratory-adapted strains of HCMV generally …