[HTML][HTML] Microbial and animal rhodopsins: structures, functions, and molecular mechanisms

OP Ernst, DT Lodowski, M Elstner, P Hegemann… - Chemical …, 2014 - ACS Publications
Organisms of all domains of life use photoreceptor proteins to sense and respond to light.
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …

The form and function of channelrhodopsin

K Deisseroth, P Hegemann - Science, 2017 - science.org
BACKGROUND Channelrhodopsins (ChRs) are naturally occurring light-gated ion channels
that are important for allowing motile algal cells to find suitable light levels. In neuroscience …

Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics

EG Govorunova, OA Sineshchekov, R Janz, X Liu… - Science, 2015 - science.org
Light-gated rhodopsin cation channels from chlorophyte algae have transformed
neuroscience research through their use as membrane-depolarizing optogenetic tools for …

Crystal structure of the channelrhodopsin light-gated cation channel

HE Kato, F Zhang, O Yizhar, C Ramakrishnan… - Nature, 2012 - nature.com
Channelrhodopsins (ChRs) are light-gated cation channels derived from algae that have
shown experimental utility in optogenetics; for example, neurons expressing ChRs can be …

Conversion of channelrhodopsin into a light-gated chloride channel

J Wietek, JS Wiegert, N Adeishvili, F Schneider… - Science, 2014 - science.org
The field of optogenetics uses channelrhodopsins (ChRs) for light-induced neuronal
activation. However, optimized tools for cellular inhibition at moderate light levels are …

Biophysics of channelrhodopsin

F Schneider, C Grimm… - Annual review of …, 2015 - annualreviews.org
Channelrhodopsins (ChRs) are directly light-gated ion channels that function as sensory
photoreceptors in flagellated green algae, allowing these algae to identify optimal light …

[HTML][HTML] Channelrhodopsin unchained: structure and mechanism of a light-gated cation channel

VA Lórenz-Fonfría, J Heberle - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
The new and vibrant field of optogenetics was founded by the seminal discovery of
channelrhodopsin, the first light-gated cation channel. Despite the numerous applications …

Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2

J Kuhne, J Vierock, SA Tennigkeit… - Proceedings of the …, 2019 - National Acad Sciences
Although channelrhodopsin (ChR) is a widely applied light-activated ion channel, important
properties such as light adaptation, photocurrent inactivation, and alteration of the ion …

[HTML][HTML] Characterization of a highly efficient blue-shifted channelrhodopsin from the marine alga Platymonas subcordiformis

EG Govorunova, OA Sineshchekov, H Li, R Janz… - Journal of Biological …, 2013 - ASBMB
Rhodopsin photosensors of phototactic algae act as light-gated cation channels when
expressed in animal cells. These proteins (channelrhodopsins) are extensively used for …

Early Formation of the Ion‐Conducting Pore in Channelrhodopsin‐2

J Kuhne, K Eisenhauer, E Ritter… - Angewandte Chemie …, 2015 - Wiley Online Library
Channelrhodopsins (ChRs) are light‐gated ion channels that are widely used in
optogenetics. They allow precise control of neuronal activity with light, but a detailed …