Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic
target. Here we report the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the
transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I …

Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful
components and maintains cellular homeostasis in response to a series of extracellular …

Mitochondria have emerged as key participants in and regulators of myocardial injury during
ischemia and reperfusion. This review examines the sites of damage to cardiac …

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

Signal transducer and activator of transcription 3 (STAT3) is one of seven STAT family
members involved with the regulation of cellular growth, differentiation and survival. STAT …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …