Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment,
innovation and development of new effective anticancer candidates still represents a …

Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds.
They are important and widely represented in medicinal chemistry as they are structural …

DNA gyrase and topoisomerase IV (topo IV) inhibitors are among the most interesting
antibacterial drug classes without antibacterial pipeline representative. Twenty-four new …

Here, we present a new series of hydrazide-bearing class I selective HDAC inhibitors
designed based on panobinostat. The cap, linker, and zinc-binding group were derivatized …

The substrate scope of the procedure for the synthesis of 2-[2-(4-R-benzoyl)
hydrazinylidene]-4-oxobutanoic acids was expanded, and their intramolecular cyclization in …

Aim: The previously reported dual histone deacetylase type II (HDAC II)/topoisomerase type
I (Topo I) inhibitors suffer pharmacokinetic limitations because of their huge molecular …

The development of NSAIDs/iNOS inhibitor hybrids is a new strategy for the treatment of
inflammatory diseases by suppression of the overproduction of PGE 2 and NO. A novel …

Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …

A method for the synthesis of substituted 4-(het) aryl-4-oxo-2-thienylaminobut-2-enoic acids
containing a nitrile substituent in the thiophene ring was proposed. Intramolecular …

In this Perspective, we have brought together available biological evidence on hydrazides
as histone deacetylase inhibitors (HDACis) and as a distinct type of Zn-binding group (ZBG) …