The functional diversity of natural killer (NK) cell repertoires stems from differentiation,
homeostatic, receptor–ligand interactions and adaptive-like responses to viral infections. In …

Immune checkpoint inhibitors (ICIs) are an expanding class of immunotherapeutic agents
with the potential to cure cancer. Despite the outstanding clinical response in patient …

Many mechanisms underlying an effective immunotherapy-induced antitumour response are
transient and critically time dependent. This is equally true for several immunological events …

Adding anti–programmed cell death protein 1 (anti–PD-1) to 5-fluorouracil (5-FU)/platinum
improves survival in some advanced gastroesophageal adenocarcinomas (GEA). To …

The tumor microenvironment (TME) contains a number of immune-suppressive cells such as
T helper 1–polarized regulatory T cells (TH1-Treg cells). However, little is known about the …

The use of large transcriptome datasets has greatly improved our understanding of the
tumor microenvironment (TME) and helped develop precise immunotherapies. The growing …

The lack of comprehensive diagnostics and consensus analytical models for evaluating the
status of a patient's immune system has hindered a wider adoption of immunoprofiling for …

Radiation therapy (RT) combined with CTLA4 blockers converts immunosuppressed (cold)
mouse triple negative breast cancers (TNBCs) into immune infiltrated (hot) lesions. We have …

Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting
anticancer response, has emerged as a promising approach for counteracting the evasive …

Osteosarcoma is the most common primary malignant bone tumor with elevated disability
and mortality rates in children and adolescents and the therapeutic effect for osteosarcoma …