Nanomechanical mapping of soft materials with the atomic force microscope: methods, theory and applications

R Garcia - Chemical Society Reviews, 2020 - pubs.rsc.org
Fast, high-resolution, non-destructive and quantitative characterization methods are needed
to develop materials with tailored properties at the nanoscale or to understand the …

Scanning probe microscopy

K Bian, C Gerber, AJ Heinrich, DJ Müller… - Nature Reviews …, 2021 - nature.com
Scanning probe microscopy (SPM), a key invention in nanoscience, has by now been
extended to a wide spectrum of basic and applied fields. Its application to basic science led …

Opportunities and challenges for biosensors and nanoscale analytical tools for pandemics: COVID-19

N Bhalla, Y Pan, Z Yang, AF Payam - ACS nano, 2020 - ACS Publications
Biosensors and nanoscale analytical tools have shown huge growth in literature in the past
20 years, with a large number of reports on the topic of 'ultrasensitive','cost-effective', and …

Atomic force microscopy-based mechanobiology

M Krieg, G Fläschner, D Alsteens, BM Gaub… - Nature Reviews …, 2019 - nature.com
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Tau protein liquid–liquid phase separation can initiate tau aggregation

S Wegmann, B Eftekharzadeh, K Tepper… - The EMBO …, 2018 - embopress.org
The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …

Force spectroscopy of single cells using atomic force microscopy

A Viljoen, M Mathelié-Guinlet, A Ray… - Nature Reviews …, 2021 - nature.com
Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

Bacterial adhesion at the single-cell level

C Berne, CK Ellison, A Ducret, YV Brun - Nature Reviews Microbiology, 2018 - nature.com
The formation of multicellular microbial communities, called biofilms, starts from the
adhesion of a few planktonic cells to the surface. The transition from a free-living planktonic …

Imaging modes of atomic force microscopy for application in molecular and cell biology

YF Dufrêne, T Ando, R Garcia, D Alsteens… - Nature …, 2017 - nature.com
Atomic force microscopy (AFM) is a powerful, multifunctional imaging platform that allows
biological samples, from single molecules to living cells, to be visualized and manipulated …

Atomic force microscopy-based force spectroscopy and multiparametric imaging of biomolecular and cellular systems

DJ Müller, AC Dumitru, C Lo Giudice… - Chemical …, 2020 - ACS Publications
During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

L Sborgi, S Rühl, E Mulvihill, J Pipercevic… - The EMBO …, 2016 - embopress.org
Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These
caspases are activated within multi‐protein inflammasome complexes that assemble in …