The small heat shock protein Hsp27 or its murine homologue Hsp25 acts as an ATP-
independent chaperone in protein folding, but is also implicated in architecture of the …

Biomarkers are urgently needed for the diagnosis and monitoring of disease progression in
Parkinson's disease. Both DJ-1 and α-synuclein, two proteins critically involved in …

Protein phosphorylation is a central regulatory mechanism of cell signaling pathways. This
highly controlled biochemical process is involved in most cellular functions, and defects in …

Abstract miR‐17‐5p is overexpressed in hepatocellular carcinoma (HCC), but the specific
regulatory mechanisms of miR‐17‐5p in HCC remain unknown. We investigated the …

The co-administration of glial cell line-derived neurotrophic factor (GDNF) and mesenchymal
stem cells (MSCs) in hydrogels (HGs) has emerged as a powerful strategy to enhance the …

Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) are
'protein misfolding disorders' of the mature nervous system that are characterized by the …

Retinal pigment epithelium (RPE)-derived membranous debris named blebs, may
accumulate and contribute to sub-RPE deposit formation, which is the earliest sign of age …

Parkinson's disease is a multifactorial, neurodegenerative disease where etiopathogenetic
mechanisms are not fully understood. Animal models like the neurotoxic 6-OHDA …

The supporting role of urokinase-type plasminogen activator (uPA) and its inhibitor
plasminogen activator inhibitor 1 (PAI-1) in migration and invasion is well known. In addition …

The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged
with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's …