Chronotherapy is a pharmaceutical intervention that considers the patient's internal
circadian time to adjust dosing time. Although it can dramatically improve drug efficacy and …

Mathematical modeling has provided quantitative information consistent with experimental
data, greatly improving our understanding of the progression of type 1 and type 2 diabetes …

The accurate regulation of glucose within humans is an essential feature of homeostasis. It
optimises energy release in the muscles and organs. Glucose rhythms driven by internal …

Cortisol is an essential steroid hormone, synthesized from cholesterol and released from the
adrenal gland. Cortisol is mostly known for its implication in physiological changes …

Rhythmic hormonal secretion is key for sustaining health. While a central pacemaker in the
hypothalamus is the main driver of circadian periodicity, many hormones oscillate with …

Stress is defined as a disruption of homeostatic balance by a real or interpreted threat.
These threatening stimuli trigger neuronal responses in the brain that cause an immediate …

Endocrine disorders are complex diseases threatening global health with high incidences.
Diabetes is the leading endocrine disease affecting socio-economic development and has …

Rhythmic hormonal secretion is key for sustaining health. While a central pacemaker in the
hypothalamus is the main driver of circadian periodicity, many hormones oscillate with …

The purpose of this chapter is to discuss the history and impact of interdisciplinary research
in the life sciences, with a focus on quantitative approaches. It examines the evolution of …