In this article, we briefly summarized evidence that cellular phosphate burden from
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …

Together with fibroblast growth factors (FGFs) 19 and 21, FGF23 is an endocrine member of
the family of FGFs. Mainly secreted by bone cells, FGF23 acts as a hormone on the kidney …

Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters
such as oxygen (p O2), extracellular acidosis (pHe), and concentration of interstitial …

Simple Summary Minerals are important but often overlooked compounds that are required
for a variety of cellular biochemical processes and pathways that regulate cell proliferation …

Alcohol consumption is associated with an increased risk of breast cancer, even at low
alcohol intake levels, but public awareness of the breast cancer risk associated with alcohol …

Recently reported findings from major clinical trials show no cancer protection from vitamin
D supplementation, and results from observational studies of vitamin D in cancer prevention …

Cancer cells show increased glutamine consumption. The glutaminase (GLS) enzyme
controls a limiting step in glutamine catabolism. Breast tumors, especially the triple-negative …

In addition to their standard inorganic phosphate (Pi) nutritional function, Pi transporters
have additional roles in several cells, including Pi sensing (the so-called transceptor) and a …

Next to smoking, obesity is the second leading preventable risk factor for cancer, but
increasing rates of obesity and overweight are estimated to overtake smoking as the leading …

Purpose Hypoxia and acidosis are recognized tumor microenvironment (TME) biomarkers of
cancer progression. Alterations in cancer redox status and metabolism are also associated …