Pyroptosis, a regulated form of pro-inflammatory cell death, is characterised by cell lysis and
by the release of cytokines, damage-and pathogen-associated molecular patterns. It plays …

ABSTRACT Introduction Wiskott–Aldrich syndrome (WAS) serves as the prototype of how
variants in a gene, which encodes a protein central to actin cytoskeletal homeostasis can …

Neutrophil-directed motility is necessary for host defense, but its dysregulation can also
cause collateral tissue damage. Actinopathies are monogenic disorders that affect the actin …

Wiskott-Aldrich syndrome (WAS) is a severe X-linked primary immunodeficiency resulting
from a diversity of mutations distributed across all 12 exons of the WAS gene. WAS encodes …

Background Sponge holobionts (ie, the host and its associated microbiota) play a key role in
the cycling of dissolved organic matter (DOM) in marine ecosystems. On coral reefs, an …

The actin cytoskeleton (AC) undergoes rapid remodelling to coordinate cellular processes
during signal transduction, including changes in actin nucleation, crosslinking, and …

The serine/threonine phosphatase calcineurin is a component of the T cell receptor (TCR)
signalosome, where it promotes T cell activation by dephosphorylating Lck S59. Using small …

Introduction: The actin cytoskeleton remodels to enable diverse processes essential to
immunity, such as cell adhesion, migration and phagocytosis. A panoply of actin-binding …

Wiskott-Aldrich syndrome (WAS)(MIM# 301000) is a rare X-linked primary immunodeficiency
due to mutations in the WAS gene, characterized by thrombocytopenia with small platelets …

Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site,
the interplay between effector immune cells and cancer cells determines the balance …