Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

P450 TleB catalyzes the oxidative cyclization of the dipeptide N-methylvalyl-tryptophanol
into indolactam V through selective intramolecular C–H bond amination at the indole C4 …

Covering: up to 2018 With contributions from the global natural product (NP) research
community, and continuing the Raw Data Initiative, this review collects a comprehensive …

Marine bacteria are excellent yet often underexplored sources of structurally unique
bioactive natural products. In this review we cover the diversity of marine bacterial …

Microbial sulfur‐containing secondary metabolites show various biological activities, but the
C− S bond‐forming in their biosynthetic metabolism has not been thoroughly understood …

Tuberculosis (TB) has become one of the most significant public health problems in recent
years. Antibiotic therapy remains the mainstay of TB control strategies, but the increasing …

The P450 monooxygenase TleB (CYP107E48) catalyzes intramolecular C–S bond
formation in a thiol-containing substrate, yielding two sulfur-containing indolactam …

Direct cloning of natural product pathways for efficient refactoring and heterologous
expression has become an important strategy for microbial natural product research and …

The marine actinomycete genus Salinispora is a remarkably prolific source of structurally
diverse and biologically active secondary metabolites. Herein, we select the model …