Background & Objective: Cannabis is one of the earliest cultivated plants. Cannabis of
industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is …

This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

This paper is the thirty-eighth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2015 …

Cannabinoids include the active constituents of Cannabis or are molecules that mimic the
structure and/or function of these Cannabis-derived molecules. Cannabinoids produce …

Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability.
The cognitive deficits in the mouse model for this disorder, the Fragile X Mental Retardation …

The number of annual cannabinoid users exceeds 100,000,000 globally and an estimated
9% of these individuals will suffer from dependency. Although exogenous cannabinoids, like …

Cannabinoid (CB) and opioid systems are both involved in analgesia, food intake, mood
and behavior. Due to the co-localization of µ-opioid (MOR) and CB1 receptors in various …

A growing amount of data demonstrates the interactions between cannabinoid, opioid and
the transient receptor potential (TRP) vanilloid type 1 (TRPV1) receptors. These interactions …

Cannabinoid subtype 1 receptor (CB1R) antagonists were originally developed as anti-
obesity agents. Unfortunately, SR1417116A (rimonabant), the first marketed inverse agonist …

Rimonabant is a potent and selective cannabinoid CB1 receptor antagonist widely used in
animal and clinical studies. Besides its antagonistic properties, numerous studies have …