It was once widely held that nearly all reactions in biology were catalyzed via mechanisms
involving paired electron species. Beginning approximately 40 years ago, this paradigm was …

Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

Polyketide biosynthesis: a millennium review - Natural Product Reports (RSC Publishing)
DOI:10.1039/A909079G Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article …

Polyketide natural products constitute a broad class of compounds with diverse structural
features and biological activities. Their biosynthetic machinery, represented by type I …

A novel protein superfamily with over 600 members was discovered by iterative profile
searches and analyzed with powerful bioinformatics and information visualization methods …

Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Covering: up to the end of 2006 This review chronicles the synergistic growth of the fields of
fatty acid and polyketide synthesis over the last century. In both animal fatty acid synthases …

Bacterial secondary metabolites are widely used as antibiotics, anticancer drugs,
insecticides and food additives. Attempts to engineer their biosynthetic gene clusters (BGCs) …

Spin-center shift (SCS) is a radical process involving 1, 2-radical translocation along with a
two-electron ionic movement, such as elimination of an adjacent leaving group. Such a …