ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

[HTML][HTML] Novel PET imaging of inflammatory targets and cells for the diagnosis and monitoring of giant cell arteritis and polymyalgia rheumatica

KSM van der Geest, M Sandovici, PH Nienhuis… - Frontiers in …, 2022 - frontiersin.org
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

In vivo Imaging Technologies to Monitor the Immune System

CE McCarthy, JM White, NT Viola… - Frontiers in …, 2020 - frontiersin.org
The past two decades have brought impressive advancements in immune modulation,
particularly with the advent of both cancer immunotherapy and biologic therapeutics for …

PET imaging of immune checkpoint proteins in oncology

A Bouleau, V Lebon, C Truillet - Pharmacology & Therapeutics, 2021 - Elsevier
Despite the remarkable clinical successes of immune checkpoint inhibitors (ICIs) in various
advanced cancers, response is still limited to a subset of patients that generally exhibit …

Advances in chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma

Z Yin, Y Zhang, X Wang - Biomarker Research, 2021 - Springer
B-cell non-Hodgkin lymphoma (B-NHL) is a group of heterogeneous disease which remains
incurable despite developments of standard chemotherapy regimens and new therapeutic …

Promising potential of a 18F-labelled small-molecular radiotracer to evaluate PD-L1 expression in tumors by PET imaging

G Lv, Y Miao, Y Chen, C Lu, X Wang, M Xie, L Qiu… - Bioorganic …, 2021 - Elsevier
Programmed death ligand 1 (PD-L1) expression level is a reproducible biomarker for
guiding stratification of patients to immunotherapy. However, the most widely used …

ImmunoPET: harnessing antibodies for imaging immune cells

AM Wu, N Pandit-Taskar - Molecular Imaging and Biology, 2022 - Springer
Dramatic, but uneven, progress in the development of immunotherapies for cancer has
created a need for better diagnostic technologies including innovative non-invasive imaging …

Molecular imaging of pancreatic ductal adenocarcinoma

W Huang, G Huang, S An, J Liu - View, 2023 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC), a deadly cancer characterized by multiple
molecular alterations, remains the most lethal cancer, with a 5‐year survival rate of about 3 …

Antibody engineering for nuclear imaging and radioimmunotherapy

C Rodriguez, S Delaney, SM Sarrett… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Radiolabeled antibodies have become indispensable tools in nuclear medicine. However,
the natural roles of antibodies within the immune system mean that they have several …

Synthetic 18 F labeled biomolecules that are selective and promising for PET imaging: Major advances and applications

M Lamba, PR Singh, A Bandyopadhyay… - RSC Medicinal …, 2024 - pubs.rsc.org
The concept of positron emission tomography (PET) based imaging was developed more
than 40 years ago. It has been a widely adopted technique for detecting and staging …