[HTML][HTML] Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA

Y Wang, X Meng, A Wang, X Xie, Y Pan… - … England Journal of …, 2021 - Mass Medical Soc
Background Comparisons between ticagrelor and clopidogrel for the secondary prevention
of stroke in CYP2C19 loss-of-function carriers have not been extensively performed …

Non-stenotic carotid plaques in embolic stroke of unknown source

J Kamtchum-Tatuene, AZ Nomani, S Falcione… - Frontiers in …, 2021 - frontiersin.org
Embolic stroke of unknown source (ESUS) represents one in five ischemic strokes.
Ipsilateral non-stenotic carotid plaques are identified in 40% of all ESUS. In this narrative …

The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack

JH McDermott, M Leach, D Sen, CJ Smith… - Expert review of …, 2022 - Taylor & Francis
Introduction Clopidogrel is an antiplatelet agent recommended for secondary prevention of
ischemic stroke (IS) and transient ischemic attack (TIA). Conversion of clopidogrel to its …

Comparison of ticagrelor vs clopidogrel in addition to aspirin in patients with minor ischemic stroke and transient ischemic attack: a network meta-analysis

R Lun, S Dhaliwal, G Zitikyte, DC Roy, B Hutton… - JAMA …, 2022 - jamanetwork.com
Importance Dual antiplatelet therapy (DAPT) with clopidogrel and aspirin is effective in
preventing recurrent strokes after minor ischemic stroke or transient ischemic attack (TIA) …

[HTML][HTML] Dual antiplatelet therapies and causes in minor stroke or transient ischemic attack: a prespecified analysis in the CHANCE-2 Trial

X Xie, J Jing, X Meng, SC Johnston, PM Bath, Z Li… - Stroke, 2023 - journals.lww.com
BACKGROUND: It is unclear whether patients with different stroke/transient ischemic attack
etiologies benefit differently from gene-directed dual antiplatelet therapy. This study …

Time course for benefit and risk with ticagrelor and aspirin in individuals with acute ischemic stroke or transient ischemic attack who carry CYP2C19 loss-of-function …

Y Pan, X Meng, A Jin, SC Johnston, H Li… - JAMA …, 2022 - jamanetwork.com
Importance Dual antiplatelet therapy (DAPT) with ticagrelor and aspirin has been found to
be effective for secondary prevention after minor ischemic stroke or transient ischemic attack …

CYP2C19 loss‐of‐function alleles and use of omeprazole or esomeprazole increase the risk of cardiovascular outcomes in patients using clopidogrel

M Ramste, M Ritvos, S Häyrynen… - Clinical and …, 2023 - Wiley Online Library
Our aim was to investigate in a real‐life prospective patient cohort how CYP2C19 loss‐of‐
function (LOF) variants and CYP2C19 inhibitor omeprazole or esomeprazole influence the …

Stroke recurrence and antiplatelets in posterior versus anterior circulation minor stroke or transient ischemic attack

H Liu, J Jing, A Wang, Q Xu, X Meng, H Li, Z Li, Y Wang - Stroke, 2023 - Am Heart Assoc
Background: It is unclear whether infarct location affects stroke recurrence after index
ischemic stroke. We aimed to compare the risk of stroke recurrence and the responses to …

Correlations among peripheral blood markers, white matter hyperintensity, and cognitive function in patients with non-disabling ischemic cerebrovascular events

B Li, B Du, Z Gu, C Wu, Y Tan, C Song, Y Xu… - Frontiers in Aging …, 2022 - frontiersin.org
Background Both inflammation and cerebral white matter injury are closely associated with
vascular cognitive impairment (VCI). The aim of this study was to analyze the correlation …

Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial

X Zhang, J Jing, A Wang, X Xie, SC Johnston… - Stroke and Vascular …, 2024 - svn.bmj.com
Objectives Evidence of the optimal antiplatelet therapy for elderly patients who had a stroke
is limited, especially those elder than 80 years. This study aimed to explore the efficacy and …