In 2015, lung cancer accounted for an estimated 221,200 new cancer diagnoses and
158,040 deaths in the United States, with the majority being attributable to cigarette …

Altered DNA methylation is ubiquitous in human cancers and specific methylation changes
are often correlated with clinical features. DNA methylation biomarkers, which use those …

Introduction Recently, analysis of DNA methylation of the SHOX2 locus was shown to
reliably identify lung cancer in bronchial aspirates of patients with disease. As a plasma …

BACKGROUND Circulating cell-free DNA methylation testing in blood has recently received
regulatory approval for screening of colorectal cancer. Its application in other clinical …

DNA methylation is an important molecular modification that plays a key role in the
expression of cancer genes. Evaluation of epigenetic changes, hypomethylation and …

The exceptional high mortality of lung cancer can be instigated to a high degree by late
diagnosis. Despite the plethora of studies on potential molecular biomarkers for lung cancer …

In the identification of subjects with lung cancer, increased DNA methylation of the SHOX2
gene locus in bronchial aspirates has previously been proven to be a clinically valuable …

Pancreatic cancer (PC) is the fourth leading cause of cancer deaths in the United States with
a five-year patient survival rate of only 6%. Early detection and treatment of this disease is …

Purpose: Epigenetic host cell changes involved in cervical cancer development following a
persistent high-risk human papillomavirus (hrHPV) infection, provide promising markers for …

Biomarkers that facilitate prediction of disease progression in lung cancer patients might be
clinically valuable in optimizing individualized therapy. In this study, the ability of the DNA …