Bone remodeling replaces old and damaged bone with new bone through a sequence of
cellular events occurring on the same surface without any change in bone shape. It was …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Much of the work conducted on adult stem cells has focused on mesenchymal stem cells
(MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived …

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation,
migration, differentiation, and survival of many different cell types. It influences such diverse …

Objective To compare the chondrogenic potential of human bone marrow–derived
mesenchymal stem cells (BMSC) and adipose tissue–derived stromal cells (ATSC), because …

Osteoblast differentiation is a multistep series of events modulated by an integrated cascade
of gene expression that initially supports proliferation and the sequential expression of …

We previously showed that anti-fibronectin antibodies or soluble fibronectin fragments
containing the central cellbinding domain inhibit formation of mineralized nodules by fetal …

Numerous techniques are currently used to characterize biological mineralization in intact
tissues and cell cultures; the von Kossa staining method, electron microscopic analysis …

Osteoporosis is an age-related disease that affects millions of people. Growth differentiation
factor 11 (GDF11) is a secreted member of the transforming growth factor beta (TGF-β) …

The secretion of fibronectin by differentiating osteoblasts and its accumulation at sites of
osteogenesis suggest that fibronectin participates in bone formation. To test this directly, we …