Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …

Applications of clustering algorithms in biomedical research are ubiquitous, with typical
examples including gene expression data analysis, genomic sequence analysis, biomedical …

Standardization of immunophenotyping procedures has become a high priority. We have
developed a suite of whole-blood, syringe-based assay systems that can be used to …

Abstract High hyperdiploid (51–67 chromosomes) acute lymphoblastic leukemia (ALL) is
one of the most common childhood malignancies, comprising 30% of all pediatric B cell …

Abstract High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic
abnormality pattern in childhood B‐cell precursor acute lymphoblastic leukemia (ALL) …

Hyperdiploidy is the largest genetic entity B-cell precursor acute lymphoblastic leukemia in
children. The diagnostic hallmark of its two variants that will be discussed in detail herein is …

Gene expression analyses were performed on 121 consecutive childhood leukemias (87 B-
lineage acute lymphoblastic leukemias (ALLs), 11 T-cell ALLs and 23 acute myeloid …

High hyperdiploid acute lymphoblastic leukemia (ALL) is one of the most common
malignancies in children. It is characterized by gain of chromosomes, typically+ X,+ 4,+ 6,+ …

There is increasing evidence for a strong inherited genetic basis of susceptibility to acute
lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B …

Hyperdiploidy, ie gain of whole chromosomes, is one of the most common genetic features
of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly …