Depression's burden of disease goes beyond functioning and quality of life and extends to
somatic health. Results from longitudinal cohort studies converge in illustrating that major …

Accumulating evidence indicates that patients with severe mental disorders, including major
depression, bipolar disorder and schizophrenia present with various alterations of the gut …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

This review will discuss the role of childhood trauma in bipolar disorders. Relevant studies
were identified via Medline (PubMed) and PsycINFO databases published up to and …

Objectives To provide a quantitative and qualitative synthesis of the available evidence on
the role of Hypothalamic–Pituitary–Adrenal (HPA) axis in the pathophysiology of Bipolar …

The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with
conflicting results. An umbrella review of meta-analyses of non-genetic peripheral …

The most common mood disorders are major depressive disorders and bipolar disorders
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …

The experience of childhood trauma (CT) and stressful life events (SLEs) is associated with
subsequent development of a variety of mental health conditions, including psychotic illness …

People with psychotic disorders show abnormalities in several organ systems in addition to
the central nervous system (CNS); and this contributes to excess mortality. However, it is …

There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …