High‐throughput metabolomics by 1D NMR

A Vignoli, V Ghini, G Meoni, C Licari… - Angewandte Chemie …, 2019 - Wiley Online Library
Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of
the‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites …

Metabolomics for clinical use and research in chronic kidney disease

B Hocher, J Adamski - Nature Reviews Nephrology, 2017 - nature.com
Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …

A reference map of potential determinants for the human serum metabolome

N Bar, T Korem, O Weissbrod, D Zeevi, D Rothschild… - Nature, 2020 - nature.com
The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease

Y Talmor-Barkan, N Bar, AA Shaul, N Shahaf… - Nature medicine, 2022 - nature.com
Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …

[HTML][HTML] Interplay between the human gut microbiome and host metabolism

A Visconti, CI Le Roy, F Rosa, N Rossi… - Nature …, 2019 - nature.com
The human gut is inhabited by a complex and metabolically active microbial ecosystem.
While many studies focused on the effect of individual microbial taxa on human health, their …

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

T Long, M Hicks, HC Yu, WH Biggs, EF Kirkness… - Nature …, 2017 - nature.com
Genetic factors modifying the blood metabolome have been investigated through genome-
wide association studies (GWAS) of common genetic variants and through exome …

Bioavailability of quercetin in humans with a focus on interindividual variation

AF Almeida, GIA Borge, M Piskula… - … reviews in food …, 2018 - Wiley Online Library
After consumption of plant‐derived foods or beverages, dietary polyphenols such as
quercetin are absorbed in the small intestine and metabolized by the body, or they are …

Uniqueness of the NMR approach to metabolomics

PG Takis, V Ghini, L Tenori, P Turano… - TrAC Trends in Analytical …, 2019 - Elsevier
NMR measures a relatively small portion of the human metabolome, which roughly
corresponds to all free small molecules present in concentrations≥ 1 μM. However, the …

Development and application of ultra-performance liquid chromatography-TOF MS for precision large scale urinary metabolic phenotyping

MR Lewis, JTM Pearce, K Spagou, M Green… - Analytical …, 2016 - ACS Publications
To better understand the molecular mechanisms underpinning physiological variation in
human populations, metabolic phenotyping approaches are increasingly being applied to …

Challenges of metabolomics in human gut microbiota research

KS Smirnov, TV Maier, A Walker, SS Heinzmann… - International Journal of …, 2016 - Elsevier
The review highlights the role of metabolomics in studying human gut microbial metabolism.
Microbial communities in our gut exert a multitude of functions with huge impact on human …