The relayed nuclear Overhauser effect in magnetization transfer and chemical exchange saturation transfer MRI

Y Zhou, C Bie, PCM van Zijl, NN Yadav - NMR in biomedicine, 2023 - Wiley Online Library
Magnetic resonance (MR) is a powerful technique for noninvasively probing molecular
species in vivo but suffers from low signal sensitivity. Saturation transfer (ST) MRI …

Real-time in vivo detection techniques for neurotransmitters: a review

Y Su, S Bian, M Sawan - Analyst, 2020 - pubs.rsc.org
Functional synapses in the central nervous system depend on a chemical signal exchange
process that involves neurotransmitter delivery between neurons and receptor cells in the …

Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line‐shape fitting CEST method

L Chen, PB Barker, RG Weiss… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose To obtain high‐resolution Cr and PCr maps of mouse skeletal muscle using a
polynomial and Lorentzian line‐shape fitting (PLOF) CEST method. Methods Wild‐type mice …

Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI

L Chen, Z Wei, KWY Chan, S Cai, G Liu, H Lu… - Neuroimage, 2019 - Elsevier
The goal of this study was to develop a molecular biomarker for the detection of protein
aggregation involved in Alzheimer's disease (AD) by exploiting the features of the water …

Magnetic resonance imaging of glycogen using its magnetic coupling with water

Y Zhou, PCM van Zijl, X Xu, J Xu, Y Li… - Proceedings of the …, 2020 - National Acad Sciences
Glycogen plays a central role in glucose homeostasis and is abundant in several types of
tissue. We report an MRI method for imaging glycogen noninvasively with enhanced …

Molecular imaging of brain tumors and drug delivery using CEST MRI: promises and challenges

J Huang, Z Chen, SW Park, JHC Lai, KWY Chan - Pharmaceutics, 2022 - mdpi.com
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) detects
molecules in their natural forms in a sensitive and non-invasive manner. This makes it a …

A snapshot of the vast array of diamagnetic CEST MRI contrast agents

DL Longo, A Carella, A Corrado, E Pirotta… - NMR in …, 2023 - Wiley Online Library
Since the inception of CEST MRI in the 1990s, a number of compounds have been identified
as suitable for generating contrast, including paramagnetic lanthanide complexes …

In vivo characterization of glycogen storage disease type III in a mouse model using glycoNOE MRI

Q Zeng, M Machado, C Bie, PCM van Zijl… - Magnetic resonance …, 2024 - Wiley Online Library
Purpose Glycogen storage disease type III (GSD III) is a rare inherited metabolic disease
characterized by excessive accumulation of glycogen in liver, skeletal muscle, and heart …

Design Chemical Exchange Saturation Transfer Contrast Agents and Nanocarriers for Imaging Proton Exchange in Vivo

H Su, KWY Chan - ACS nano, 2024 - ACS Publications
Chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) enables
the imaging of many endogenous and exogenous compounds with exchangeable protons …

Mechanism and quantitative assessment of saturation transfer for water‐based detection of the aliphatic protons in carbohydrate polymers

Y Zhou, PCM van Zijl, J Xu… - Magnetic resonance in …, 2021 - Wiley Online Library
Purpose CEST MRI experiments of mobile macromolecules, for example, proteins,
carbohydrates, and phospholipids, often show signals due to saturation transfer from …