Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

The family of interferon (IFN) proteins has now more than reached the potential envisioned
by early discovering virologists: IFNs are not only antivirals with a spectrum of clinical …

Highly pathogenic human respiratory coronaviruses cause acute lethal disease
characterized by exuberant inflammatory responses and lung damage. However, the factors …

Small-cell lung cancer (SCLC) is an aggressive malignancy in which inhibitors of PARP
have modest single-agent activity. We performed a phase I/II trial of combination olaparib …

The capacity of immunity to control and shape cancer, that is, cancer immunoediting, is the
result of three processes,,,,,,, that function either independently or in sequence: elimination …

Cancer cells often develop resistance to chemotherapy or irradiation through mutations in
the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular …

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of
responsive genes. IFNs were the first human proteins to be effective in cancer therapy and …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in
various tumor cells in vitro, but its physiological role in tumor surveillance remains unknown …

Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many
ways appears to be similar in humans and nonhuman primates; however, little is known …