The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …

Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the central
nervous system characterized by relapses and remissions. The risk of acquiring this …

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …

The classical twin study has been a powerful heuristic in biomedical, psychiatric and
behavioural research for decades. Twin registries worldwide have collected biological …

Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …

The contribution of genetic inheritance in multiple sclerosis was established early on.
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …

Data on familial recurrence rates of complex diseases such as multiple sclerosis give
important hints to aetiological factors such as the importance of genes and environment. By …

Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple
sclerosis (MS) account for a significant proportion of the health care burden in many …

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS)
susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to …

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating central nervous
system disorder that is more common in women, with onset often during reproductive years …