The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

A general consensus exists that IBD is associated with compositional and metabolic
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …

The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Inflammatory bowel diseases (IBDs) result in diarrhea and abdominal pain with further
potential complications such as tissue fibrosis and stenosis. Animal models help in …

Ulcerative colitis (UC) is a chronic recurrent intestinal inflammatory disease characterized by
high incidence and young onset age. Recently, there have been some interesting findings in …

The abundance of innate and adaptive immune cells that reside together with trillions of
beneficial commensal microorganisms in the mammalian gastrointestinal tract requires …

Intestinal microbiota interacts with other systems, especially the immune system, which is
responsible for protecting the body by recognizing “stranger”(pathogen associated …

Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and
have a well-appreciated role in barrier maintenance through the secretion of mucus …

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder with an
unknown etiology. IBD is composed of two different disease entities: Crohn's disease (CD) …