Fluorescent imaging of cancerous tissues for targeted surgery

L Bu, B Shen, Z Cheng - Advanced drug delivery reviews, 2014 - Elsevier
To maximize tumor excision and minimize collateral damage are the primary goals of cancer
surgery. Emerging molecular imaging techniques have made “image-guided surgery” …

[HTML][HTML] Advances in fluorescent-image guided surgery

MJ Landau, DJ Gould, KM Patel - Annals of translational medicine, 2016 - ncbi.nlm.nih.gov
Advances in fluorescent-image guided surgery - PMC Back to Top Skip to main content NIH
NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …

Image-guided surgery: are we getting the most out of small-molecule prostate-specific-membrane-antigen-targeted tracers?

AW Hensbergen, DM van Willigen… - Bioconjugate …, 2019 - ACS Publications
Expressed on virtually all prostate cancers and their metastases, the transmembrane protein
prostate-specific membrane antigen (PSMA) provides a valuable target for the imaging of …

Fluorescence in robotic surgery

D Daskalaki, F Aguilera, K Patton… - Journal of surgical …, 2015 - Wiley Online Library
Currently, there are several clinical applications for intraoperative ICG, such as identification
of vascular and biliary anatomy, assessment of organ and tissue perfusion, lymph node …

Real-time, near-infrared fluorescence imaging with an optimized dye/light source/camera combination for surgical guidance of prostate cancer

BP Neuman, JB Eifler, M Castanares… - Clinical Cancer …, 2015 - AACR
Purpose: The prostate-specific membrane antigen (PSMA) is a surface glycoprotein
overexpressed on malignant prostate cells, as well as in the neovasculature of many tumors …

Current applications of near-infrared fluorescence imaging in robotic urologic surgery: a systematic review and critical analysis of the literature

R Autorino, H Zargar, WM White, G Novara, F Annino… - Urology, 2014 - Elsevier
Herein, we provide a systematic review and critical analysis of the current evidence on the
applications of near-infrared fluorescence in robotic urologic surgery. Article selection …

Fluorescent image–guided surgery with an anti-prostate stem cell antigen (PSCA) diabody enables targeted resection of mouse prostate cancer xenografts in real time

GA Sonn, AS Behesnilian, ZK Jiang, KA Zettlitz… - Clinical Cancer …, 2016 - AACR
Purpose: The inability to visualize cancer during prostatectomy contributes to positive
margins, cancer recurrence, and surgical side effects. A molecularly targeted fluorescent …

In vivo imaging of prostate cancer using an anti-PSMA scFv fragment as a probe

C Mazzocco, G Fracasso, C Germain-Genevois… - Scientific Reports, 2016 - nature.com
We aimed to evaluate a fluorescent-labeled single chain variable fragment (scFv) of the anti-
PSMA antibody as a specific probe for the detection of prostate cancer by in vivo …

Pharmacokinetic and Biodistribution Assessment of a Near Infrared‐Labeled PSMA‐Specific Small Molecule in Tumor‐Bearing Mice

JL Kovar, LL Cheung, MA Simpson, DM Olive - Prostate cancer, 2014 - Wiley Online Library
Prostate cancer is the most frequently diagnosed cancer in men and often requires surgery.
Use of near infrared (NIR) technologies to perform image‐guided surgery may improve …

A Fluorescent, [18F]-Positron-Emitting Agent for Imaging Prostate-Specific Membrane Antigen Allows Genetic Reporting in Adoptively Transferred, Genetically …

H Guo, H Kommidi, Y Vedvyas… - ACS Chemical …, 2019 - ACS Publications
Clinical trials involving genome-edited cells are growing in popularity, where CAR-T
immunotherapy and CRISPR/Cas9 editing are more recognized strategies. Genetic …