As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …

Patient-derived tumor xenografts (PDXs), in which tumor fragments surgically dissected from
cancer patients are directly transplanted into immunodeficient mice, have emerged as a …

Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in
inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting …

Cancer-associated fibroblasts (CAFs) are major components of the carcinoma
microenvironment that promote tumor progression. However, the mechanisms by which …

Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of
carcinomas that emerge in the tumor microenvironment as a result of signals derived from …

Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …

Cancer-associated fibroblasts (CAFs) are the major components of the tumor
microenvironment. They may drive tumor progression, although the mechanisms involved …

Cancerous tissue is a complex mix of tumor cells, stromal cells and extracellular matrix
(ECM), all of which make up a disordered and aggressive niche in comparison with …

In this Review we summarize our current understanding of the biology of mesenchymal cells
of the intestinal lamina propria focusing mainly on fibroblasts and myofibroblasts. The topics …