Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
[HTML][HTML] Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP
Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …
Phospholipids critical micellar concentrations trigger different mechanisms of intrinsically disordered proteins interaction with model membranes
Amyloidogenic proteins are involved in many diseases, including Alzheimer's, Parkinson's,
and type II diabetes. These proteins are thought to be toxic for cells because of their …
and type II diabetes. These proteins are thought to be toxic for cells because of their …
Converting the Amyloidogenic Islet Amyloid Polypeptide into a Potent Nonaggregating Peptide Ligand by Side Chain-to-Side Chain Macrocyclization
M Babych, ML Garelja, PT Nguyen… - Journal of the …, 2024 - ACS Publications
The islet amyloid polypeptide (IAPP), also known as amylin, is a hormone playing key
physiological roles. However, its aggregation and deposition in the pancreatic islets are …
physiological roles. However, its aggregation and deposition in the pancreatic islets are …
Computer simulations of protein–membrane systems
The interactions between proteins and membranes play critical roles in signal transduction,
cell motility, and transport, and they are involved in many types of diseases. Molecular …
cell motility, and transport, and they are involved in many types of diseases. Molecular …
[HTML][HTML] Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges
O Press-Sandler, Y Miller - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes
(T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in …
(T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in …
Green tea extract EGCG plays a dual role in Aβ42 protofibril disruption and membrane protection: A molecular dynamic study
Amyloid plaques accumulated by the amyloid-β (Aβ) fibrillar aggregates are the major
pathological hallmark of the Alzheimer's disease (AD). Inhibiting aggregation and …
pathological hallmark of the Alzheimer's disease (AD). Inhibiting aggregation and …
[HTML][HTML] Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the …
The traditional model of protein structure determined by the amino acid sequence is today
seriously challenged by the fact that approximately half of the human proteome is made up …
seriously challenged by the fact that approximately half of the human proteome is made up …
[HTML][HTML] Recent computational studies of membrane interaction and disruption of human islet amyloid polypeptide: Monomers, oligomers and protofibrils
The amyloid deposits of human islet amyloid polypeptide (hIAPP) are found in type 2
diabetes patients. hIAPP monomer is intrinsically disordered in solution, whereas it can form …
diabetes patients. hIAPP monomer is intrinsically disordered in solution, whereas it can form …