Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Purpose: In this first-in-human, Phase 1, open-label, multicenter study, we evaluated JNJ-
64619178, a selective and potent PRMT5 inhibitor, in patients with advanced malignant …

Abstract Protein arginine methyltransferases 5 (PRMT5), a therapeutic target whose main
physiological function is mono-and symmetric dimethylation of arginine, has drawn …

The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of
metabolism and cell growth by sensing diverse environmental signals, including amino …

PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …

Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are
increasingly being recognized for their potential as drug targets. Here we report the …

Osteosarcoma (OS), the most common primary malignancy of the bone, has a poor
prognosis due to its high mortality rate and high potential for metastasis. Thus, it is urgently …

Histone modifications are an epigenetic mechanism, and the dysregulation of these proteins
is known to be associated with the initiation and progression of cancer. In the search for the …