Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

Highlights•Drug-likeness refers to the similarity between compounds and drugs; drug-like
compounds are more likely to be transformed into drugs.•Chemical structures with enhanced …

Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2
has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological …

During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

Fragment‐based drug discovery (FBDD) is now established as a complementary approach
to high‐throughput screening (HTS). Contrary to HTS, where large libraries of drug‐like …

The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as
they display vast biological activities. Recent efforts concerning the preparation of oxindole …

Highlights•Natural products show great promises in the drug repositioning campaign.•New
drug-disease associations are uncovered and discussed.•Pros and cons in natural product …