Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Extensive use of chemical pesticides poses a great threat to the environment and food
safety. The discovery of Bacillus thuringiensis (Bt) toxins with effective insecticidal activity …

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two
alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control …

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles
gambiae effectively suppressed the reproductive capability of mosquito populations reared …

Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …

Homing-based gene drives use a germline source of nuclease to copy themselves at
specific target sites in a genome and bias their inheritance. Such gene drives can be …

The sterile insect technique (SIT) is an environmentally safe and proven technology to
suppress wild populations. To further advance its utility, a novel CRISPR-based technology …

Abstract Integrated Pest Management (IPM) is a holistic approach to combat pests (including
herbivores, pathogens, and weeds) using a combination of preventive and curative actions …

Small laboratory cage trials of non-drive and gene-drive strains of the Asian malaria vector
mosquito, Anopheles stephensi, were used to investigate release ratios and other strain …

Background Gene drives based on CRISPR-Cas9 technology are increasingly being
considered as tools for reducing the capacity of mosquito populations to transmit malaria …