An assessment of EGFR and HER2 inhibitors with structure activity relationship of fused pyrimidine derivatives for breast cancer: a brief review

PS Dhiwar, GS Purawarga Matada, R Pal… - Journal of …, 2024 - Taylor & Francis
Epidermal growth factor receptor (EGFR) and its subtype human epidermal growth factor
receptor 2 (HER2) gets activated when its endogenous ligand (s) bind to its ATP binding site …

Synthetic methods for various chromeno-fused heterocycles and their potential as antimicrobial agents

N Agrawal, R Goswami, S Pathak - Medicinal Chemistry, 2024 - benthamdirect.com
Chromenes are a significant family of heterocyclic chemicals that have a wide range of
biological applications, a simple chemical structure, and only mildly undesirable side effects …

Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P …

LM Al-Harbi, EA Al-Harbi, RM Okasha… - Journal of enzyme …, 2023 - Taylor & Francis
A series of 1 H-benzo [f] chromene moieties (4a–z) were synthesised under Ultrasonic
irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray …

Discovery of pyran annulated heterocyclic scaffolds linked to carboxamide fragments: Anticancer evaluation, topoisomerase I/II, tyrosine kinase receptor inhibition and …

AM Fouda, RA El-Eisawy, MAA El-Nassag… - Journal of Molecular …, 2024 - Elsevier
A class of 4H-benzo [h] chromene (4a-h) and 1H-benzo [f] chromene (6a-h) derivatives
linked to carboxamide/carbothioamide at the 3/2-positions were designed and synthesized …

Transition-metal-free selective pyrimidines and pyridines formation from aromatic ketones, aldehydes and ammonium salts

J Chen, H Meng, F Zhang, F Xiao, GJ Deng - Green Chemistry, 2019 - pubs.rsc.org
An efficient synthesis of pyrimidines and pyridines has been developed from readily
available aromatic ketones, aldehydes and ammonium salts under transition-metal-free …

Synthesis of 1, 4-dihydropyrano [2, 3-c] pyrazole derivatives and exploring molecular and cytotoxic properties based on DFT and molecular docking studies

AM Fouda, MAA El-Nassag, AA Elhenawy… - Journal of Molecular …, 2022 - Elsevier
One-pot multicomponent reaction of ethyl 3-oxobutanoate or ethyl 3-oxo-3-
phenylpropanoate, hydrazine hydrate, malononitrile, various aldehydes in ethanolic …

A review on fused pyrimidine systems as EGFR inhibitors and their structure–activity relationship

TT Yadav, G Moin Shaikh, MS Kumar… - Frontiers in …, 2022 - frontiersin.org
Epidermal growth factor receptor (EGFR) belongs to the family of tyrosine kinase that is
activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular …

Synthesis, crystal structure, DFT studies, molecular docking, of 2-amino-6-methoxy-4-(4-nitrophenyl)-4H-benzo [h] chromene-3-carbonitrile as tyrosinase inhibitor

AAM Al-Dies, AHF Abd El-Wahab, AA Alamri… - Journal of Molecular …, 2025 - Elsevier
Abstract β-Enaminonitrile (4), was created using Ultrasonic irradiation under 60 W and
interval of two minutes at room temperature. Single crystal X-ray diffraction and multi-nuclear …

Synthesis of 9-Hydroxy-1H-Benzo[f]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, P-Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis …

FF Albalawi, MAA El-Nassag, RA El-Eisawy… - International Journal of …, 2022 - mdpi.com
β-Enaminonitriles bearing 9-hydroxy-1 H-benzo [f] chromene moiety was synthesized. The
targeted compounds were evaluated for their anti-proliferative activity against three human …

Acid-controlled multicomponent selective synthesis of 2, 4, 6-triaryl pyridines and pyrimidines by using hexamethyldisilazane as a nitrogen source under microwave …

CK Chan, YH Chung, CC Wang - RSC advances, 2022 - pubs.rsc.org
An efficient and general protocol for the synthesis of functionalized 2, 4, 6-triaryl pyridines
and pyrimidines was developed from commercially available aromatic ketones, aldehydes …