Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that falls under the
umbrella of dementia and is characterised by the presence of highly neurotoxic amyloid …

Triggering receptor expressed on myeloid cells 2 (TREM2) is strongly linked to Alzheimer's
disease (AD) risk, but its functions are not fully understood. Here, we found that TREM2 …

Osteopontin characterizes bile duct–associated macrophages a... : Hepatology Osteopontin
characterizes bile duct–associated macrophages and correlates with liver fibrosis severity in …

Advances in nanotechnology have enabled the design of nanotherapeutic platforms that
could address the challenges of targeted delivery of active therapeutic agents to the central …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane receptor
protein predominantly expressed in microglia within the central nervous system (CNS) …

Cerebral small vessel disease is one of the most common causes of cognitive decline and
stroke. While several lines of evidence have established a relationship between …

Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) is a pattern recognition receptor
on myeloid cells, and is upregulated on microglia surrounding amyloid plaques in …

Background: Individuals with specific TREM2 gene variants that encode for a Triggering
Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer's disease …

Genetic data implicate microglia as central players in brain health and disease, urging the
need to better understand what microglia do in the brain. Microglia are critical partners in …