Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells
M Abbaspour Babaei, B Kamalidehghan… - Drug design …, 2016 - Taylor & Francis
c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …
Gastrointestinal stromal tumors
M Miettinen, J Lasota - Gastroenterology Clinics, 2013 - gastro.theclinics.com
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the
gastrointestinal (GI) tract. Soon after GIST was recognized as a tumor driven by a KIT or …
gastrointestinal (GI) tract. Soon after GIST was recognized as a tumor driven by a KIT or …
Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours
J Lasota, M Miettinen - Histopathology, 2008 - Wiley Online Library
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of
the gastrointestinal tract. Despite clinicopathological differences, GISTs share oncogenic KIT …
the gastrointestinal tract. Despite clinicopathological differences, GISTs share oncogenic KIT …
Monoclonal antibody DOG1. 1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes
B Liegl, JL Hornick, CL Corless… - The American journal of …, 2009 - journals.lww.com
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the
gastrointestinal tract. Approximately 85% of GISTs harbor activating mutations in the KIT or …
gastrointestinal tract. Approximately 85% of GISTs harbor activating mutations in the KIT or …
The structure of P‐TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
S Baumli, G Lolli, ED Lowe, S Troiani, L Rusconi… - The EMBO …, 2008 - embopress.org
The positive transcription elongation factor b (P‐TEFb)(CDK9/cyclin T (CycT)) promotes
mRNA transcriptional elongation through phosphorylation of elongation repressors and …
mRNA transcriptional elongation through phosphorylation of elongation repressors and …
Gastrointestinal stromal tumors
B Liegl-Atzwanger, JA Fletcher, CDM Fletcher - Virchows Archiv, 2010 - Springer
Gastrointestinal stromal tumors (GISTs) have emerged from being poorly defined, treatment-
resistant tumors to a well-recognized, well-understood, and treatable tumor entity within only …
resistant tumors to a well-recognized, well-understood, and treatable tumor entity within only …
Sp1/NFκB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia
The biologic and clinical significance of KIT overexpression that associates with KIT gain-of-
function mutations occurring in subsets of acute myeloid leukemia (AML)(ie, core binding …
function mutations occurring in subsets of acute myeloid leukemia (AML)(ie, core binding …
Resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumors
AW Gramza, CL Corless, MC Heinrich - Clinical Cancer Research, 2009 - AACR
Gastrointestinal stromal tumors (GIST) are the most common type of sarcoma in the
gastrointestinal tract. Surgery is the primary treatment modality, but many patients suffer …
gastrointestinal tract. Surgery is the primary treatment modality, but many patients suffer …
Opportunities for improving the therapeutic ratio for patients with sarcoma
Sarcomas are mesenchymal cancers, which, in many cases, have distinctive molecular
features. Limb-sparing surgery delivered at specialised sarcoma centres as part of a …
features. Limb-sparing surgery delivered at specialised sarcoma centres as part of a …
Sustained inhibition of receptor tyrosine kinases and macrophage depletion by PLX3397 and rapamycin as a potential new approach for the treatment of MPNSTs
PP Patwardhan, O Surriga, MJ Beckman… - Clinical cancer …, 2014 - AACR
Purpose: Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive tumor
type that is resistant to chemotherapy and there are no effective therapies. MPNSTs have …
type that is resistant to chemotherapy and there are no effective therapies. MPNSTs have …