Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in
1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered …

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin
filament networks and link them to cellular membranes where they integrate cell …

Filamin A (FLNA) is a large actin-binding cytoskeletal protein that is important for cell motility
by stabilizing actin networks and integrating them with cell membranes. Interestingly, a C …

Tumor endothelial markers (TEMs) that are highly expressed in human tumor vasculature
compared with vasculature in normal tissue hold clear therapeutic potential. We report that …

The structure and molecular signature of tumor-associated vasculature are distinct from
those of the host tissue, offering an opportunity to selectively target the tumor blood vessels …

Engineering T cells to express chimeric antigen receptors (CARs) specific for antigens on
hematological cancers has yielded remarkable clinical responses, but with solid tumors …

Opioids are potent drugs that are widely used to control wound or cancer pain. Increasing
evidence suggest that opioids mediate clinically relevant effects that go beyond their …

PI3K/Akt signaling plays an important role in the regulation of cardiomyocyte death
machinery, which can cause stress-induced cardiac dysfunction. Here, we report that …

Background Many human cancer cells express filamin A (FLNA), an actin-binding structural
protein that interacts with a diverse set of cell signaling proteins, but little is known about the …

Current vascular-targeted therapies in colorectal cancer (CRC) have shown limited benefit.
The lack of novel, specific treatment in CRC has been hampered by a dearth of specific …