HIV subtype diversity worldwide

N Bbosa, P Kaleebu, D Ssemwanga - Current Opinion in HIV and …, 2019 - journals.lww.com
The dynamic change in HIV subtype distribution presents future challenges for diagnosis,
treatment and vaccine design and development. An increase in recombinant viruses …

Recombination in HIV: an important viral evolutionary strategy.

DS Burke - Emerging infectious diseases, 1997 - ncbi.nlm.nih.gov
Human immunodeficiency virus (HIV) is a diploid virus: each virion carries two complete
RNA genomic strands. Homologous recombination can occur when a cell is coinfected with …

Identification of breakpoints in intergenotypic recombinants of HIV type 1 by bootscanning

MO Salminen, JK Carr, DS Burke… - AIDS research and …, 1995 - liebertpub.com
TheHuman Immunodeficiency Virus Type I (HIV-1) gen-erates genetic diversity both by the
accumulation of point mutations and by recombination. 1-3 Evidence indicates that both of …

A computer program designed to screen rapidly for HIV type 1 intersubtype recombinant sequences

AC Siepel, AL Halpern, C Macken… - AIDS research and …, 1995 - liebertpub.com
Here we describe a simple and rapid heuristic method for detection of recombinant
sequences (or more broadly, mosaic se-quences), and its application to the env and gag …

The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin

F Gao, DL Robertson, SG Morrison, H Hui… - Journal of …, 1996 - Am Soc Microbiol
Since 1989, human immunodeficiency virus type 1 (HIV-1) has spread explosively through
the heterosexual population in Thailand. This epidemic is caused primarily by viruses …

Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure.

L Moutouh, J Corbeil… - Proceedings of the …, 1996 - National Acad Sciences
The potential contribution of recombination to the development of HIV-1 resistance to
multiple drugs was investigated. Two distinct viruses, one highly resistant to a protease …

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

H Song, EE Giorgi, VV Ganusov, F Cai… - Nature …, 2018 - nature.com
Recombination in HIV-1 is well documented, but its importance in the low-diversity setting of
within-host diversification is less understood. Here we develop a novel computational tool …

A comprehensive panel of near-full-length clones and reference sequences for non-subtype B isolates of human immunodeficiency virus type 1

F Gao, DL Robertson, CD Carruthers… - Journal of …, 1998 - Am Soc Microbiol
Non-subtype B viruses cause the vast majority of new human immunodeficiency virus type 1
(HIV-1) infections worldwide and are thus the major focus of international vaccine efforts …

Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID …

F Gao, SG Morrison, DL Robertson… - Journal of …, 1996 - Am Soc Microbiol
Present knowledge of human immunodeficiency virus type 1 (HIV-1) envelope
immunobiology has been derived almost exclusively from analyses of subtype B viruses, yet …

The emerging genetic diversity of HIV: the importance of global surveillance for diagnostics, research, and prevention

DJ Hu, TJ Dondero, MA Rayfield, JR George… - Jama, 1996 - jamanetwork.com
The discovery of highly divergent strains of human immunodeficiency virus (HIV) not reliably
detected by a number of commonly used diagnostic tests has underscored the need for …