Extensive investigation of gene fusions in cancer has led to the discovery of novel
biomarkers and therapeutic targets. To date, most studies have neglected chromosomal …

Harnessing the patient's immune system to control a tumor is a proven avenue for cancer
therapy. T cell therapies as well as therapeutic vaccines, which target specific antigens of …

Cancer-associated gene fusions are a potential source for highly immunogenic
neoantigens, but the lack of computational tools for accurate, sensitive identification of …

Somatic mutations and gene fusions can produce immunogenic neoantigens mediating
anticancer immune responses. However, their computational prediction from sequencing …

Background In cancer, genomic rearrangements can create fusion genes that either
combine protein-coding sequences from two different partner genes or place one gene …

Non-small cell lung cancer (NSCLC) is histologically classified into lung adenocarcinoma
(LUAD) and lung squamous cell carcinoma (LSCC). However, some tumors are …

Simple Summary Pheochromocytomas and paragangliomas are rare neuroendocrine
tumors that are often hereditary. Although research has advanced considerably, significant …

The broadly used 10X Genomics technology for single-cell RNA sequencing (scRNA-seq)
captures RNA 3′ ends. Thus, some reads contain part of the non-templated polyadenosine …

Whole-genome sequencing either alone or in combination with whole-transcriptome
sequencing has started to be used to analyze clinical tumor samples to improve diagnosis …

Sulfur, organosulfur compounds, and sulfides are essential parts of life. Microbial sulfate
assimilation is among the most active and ancient metabolic activities in the sulfur cycle that …