A Villar‐Piqué, T Lopes da Fonseca… - Journal of …, 2016 - Wiley Online Library
Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are …
Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …
In Parkinson's disease, the progressive neurodegeneration of nigrostriatal dopaminergic neurons in the substantia nigra pars compacta (SNc) is associated with classic motor …
Š Lehtonen, TM Sonninen, S Wojciechowski… - Frontiers in …, 2019 - frontiersin.org
Despite decades of research, current therapeutic interventions for Parkinson's disease (PD) are insufficient as they fail to modify disease progression by ameliorating the underlying …
F Samuel, WP Flavin, S Iqbal, C Pacelli… - Journal of Biological …, 2016 - ASBMB
Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains, nearly all α-syn accumulated within Lewy bodies in Parkinson disease brains is …
K Yamada, T Iwatsubo - Molecular neurodegeneration, 2018 - Springer
Background α-Synuclein is a presynaptic protein abundant in the cytoplasmic compartment of neurons, whereas its presence in the extracellular space has also been observed under …
GBA gene variants were the first genetic risk factor for Parkinson's disease. GBA encodes the lysosomal enzyme glucocerebrosidase (GBA), which is involved in sphingolipid …
Parkinson's disease (PD) is not only characterized by motor disturbances but also, by cognitive, sensory, psychiatric and autonomic dysfunction. It has been proposed that some …
AS Kulkarni, MR Burns, P Brundin… - Brain …, 2022 - academic.oup.com
The prodromal phase of Parkinson's disease is characterized by aggregation of the misfolded pathogenic protein α-synuclein in select neural centres, co-occurring with non …