Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Two-dimensional and three-dimensional cell culture systems are widely used for biological
studies, and are the basis of the organoid, tissue engineering and organ-on-chip research …

Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation.
However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically …

Biomaterial implantation is followed by an inflammatory cascade dominated by
macrophages, which determine implant acceptance or rejection through pro-and anti …

Cells alter their mechanical properties in response to their local microenvironment; this plays
a role in determining cell function and can even influence stem cell fate. Here, we identify a …

The mechanical properties of extracellular matrices can control the function of cells. Studies
of cellular responses to biomimetic soft materials have been largely restricted to hydrogels …

The spatial presentation of mechanical information is a key parameter for cell behavior. We
have developed a method of polymerization control in which the differential diffusion …

The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …

Studies of cellular mechanotransduction have converged upon the idea that cells sense
extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on …