Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …

Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Summary R-2-hydroxyglutarate (R-2HG), a metabolite produced by mutant isocitrate
dehydrogenases (IDHs), was recently reported to exhibit anti-tumor activity. However, its …

Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Herein, we use lessons learned in exercise physiology and metabolism to propose that
augmented lactate production ('lactagenesis'), initiated by gene mutations, is the reason and …

Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …

Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …

Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic
acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is …

Mitochondria have a well-recognized role in the production of ATP and the intermediates
needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate …