Biomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …

The history of polyglutamine diseases dates back approximately 20 years to the discovery of
a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of …

Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused
by the expansion of a trinucleotide CAG repeat encoding the polyglutamine tract in the first …

Endogenous protein quality control machinery has long been suspected of influencing the
onset and progression of neurodegenerative diseases characterized by accumulation of …

Despite extensive study, progress in elucidation of biological functions of amyloids and their
role in pathology is largely restrained due to the lack of universal and reliable biochemical …

Huntington disease is a dominantly inherited disease of the central nervous system. The
mutational expansion of polyglutamine beyond a critical length produces a toxic gain of …

Huntington's disease resulting from huntingtin containing an expanded polyglutamine is
associated with aggregates largely confined to neuronal inclusions, and with neuronal …

Post-translational modification (PTM) is an important mechanism in modulating a protein's
structure and can lead to substantial diversity in biological function. Compared to other forms …

Formation of intracellular mutant Huntingtin (mHtt) aggregates is a hallmark of Huntington's
disease (HD). The mechanisms underlying mHtt aggregation, however, are still not fully …

In polyglutamine diseases such as X-linked spinobulbar muscular atrophy (SBMA), it is
unknown whether the toxic form of the protein is an insoluble or soluble aggregate or a …