Following the spread of the SARS-CoV-2 infection and coronavirus disease 2019 (COVID-
19) to a global pandemic, concerns have arisen for the disease impact in at-risk populations …

The difference in morbidity and mortality between adult and pediatric coronavirus disease
2019 infections is dramatic. Understanding pediatric‐specific acute and delayed immune …

Abstract Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging
virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the …

Studies during the COVID-19 pandemic showed that children had heightened nasal innate
immune responses compared with adults. To evaluate the role of nasal viruses and bacteria …

Respiratory syncytial virus (RSV) selectively targets ciliated cells in human bronchial
epithelium and can cause bronchiolitis and pneumonia, mostly in infants. To identify …

Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-
19) when compared to adults. There is a strong body of evidence that children are also less …

Immature innate and adaptive immunity and vulnerability of narrower airways to obstruction
increase the susceptibility of infants to severe respiratory syncytial virus (RSV) disease. In …

Organoids have become a prominent model system in pulmonary research. The ability to
establish organoid cultures directly from patient tissue has expanded the repertoire of …

Age-related lung function decline is associated with small airway closure and gas trapping.
The mechanisms which cause these changes are not fully understood. It has been …

Simple Summary Respiratory viral infections are among the most common diseases that
affect children. Respiratory syncytial virus (RSV) is the most common pathogen causing …