The host–parasite schistosome relationship relies heavily on the interplay between the
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …

Recent studies have shown that host genetics is an important determinant of the intensity of
infection and morbidity due to human helminths. Epidemiological studies of a number of …

Helminth infection currently affect over 2 billion people worldwide, with those with the most
pathologies and morbidities, living in regions with unequal and disproportionate access to …

Th-2 immune mechanisms are involved in the pathology of asthma and in the protective
immune response to parasitic worms. Common upregulating genetic variants of Th-2 …

Schistosoma mansoni infection, associated morbidity and symptoms were studied in Piida
fishing community at Butiaba, along Lake Albert, Uganda, from November 1996 to January …

Parasitic worm infection, allergy and asthma involve increased IgE production, eosinophil
activity, mucus secretion and smooth muscle reactivity, effected through Th-2 immune …

Infection with the trematode helminth Schistosoma mansoni results in a parasite egg-
induced, CD4 T-cell-mediated, hepatointestinal granulomatous and fibrosing inflammation …

Parasites still impose a high death and disability burden on human populations, and are
therefore likely to act as selective factors for genetic adaptations. Genetic epidemiological …

Infection with the trematode parasite Schistosoma mansoni results in a distinct heterogeneity
of disease severity, both in humans and in an experimental mouse model. Severe disease is …

To estimate their heritable component of risk for Schistosoma haematobium infection
intensity and disease, we performed a community-based family study among an endemic …