Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …

For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

The progression of cancer is not only about the tumor cell itself, but also about other
involved players including cancer cell recruited immune cells, their released pro …

Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

Prostate cancer stem cells (PCSCs) play a critical role in prostate cancer progression and
metastasis, which remains an obstacle for successful prostate cancer treatment. Tumor …

Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend
against pathogens; however, their infiltration into tumors has been associated with adverse …

CXCL1 is one of the most important chemokines, part of a group of chemotactic cytokines
involved in the development of many inflammatory diseases. It activates CXCR2 and, at high …

Abstract Background Circular RNAs (circRNAs) are a novel type of noncoding RNAs and
play important roles in tumorigenesis, including gastric cancer (GC). However, the functions …

The combination of immune checkpoint blockade with chemotherapy is currently under
investigation as a promising strategy for the treatment of triple negative breast cancer …