Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders
S Singh, AS Grewal, R Grover, N Sharma, B Chopra… - Bioorganic …, 2022 - Elsevier
The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …
PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011–2014)
AK Tamrakar, CK Maurya, AK Rai - Expert opinion on therapeutic …, 2014 - Taylor & Francis
Introduction: Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the
negative regulation of insulin signal transduction pathway and has emerged as novel …
negative regulation of insulin signal transduction pathway and has emerged as novel …
Use of π–π forces to steer the assembly of chromone derivatives into hydrogen bonded supramolecular layers: crystal structures and Hirshfeld surface analyses
SK Seth, D Sarkar, T Kar - CrystEngComm, 2011 - pubs.rsc.org
Two chromone derivatives C11H10O3 (1) and C11H10O2 (2) have been synthesized and
characterized by X-ray structural studies with a detailed analysis of the Hirshfeld surfaces …
characterized by X-ray structural studies with a detailed analysis of the Hirshfeld surfaces …
PTP1b inhibition, a promising approach for the treatment of diabetes type II
P Eleftheriou, A Geronikaki… - Current topics in medicinal …, 2019 - ingentaconnect.com
Background: Diabetes Mellitus (DM), is a metabolic disorder characterized by high blood
glucose levels. The main types of diabetes mellitus are Diabetes mellitus type I, Diabetes …
glucose levels. The main types of diabetes mellitus are Diabetes mellitus type I, Diabetes …
Cellular chromium enhances activation of insulin receptor kinase
H Wang, A Kruszewski, DL Brautigan - Biochemistry, 2005 - ACS Publications
Chromium has been recognized for decades as a nutritional factor that improves glucose
tolerance by enhancing in vivo insulin action, but the molecular mechanism is unknown …
tolerance by enhancing in vivo insulin action, but the molecular mechanism is unknown …
Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus
Diabetes mellitus is a systemic disease responsible for morbidity in the western world and is
gradually becoming prevalent in developing countries too. The prevalence of diabetes is …
gradually becoming prevalent in developing countries too. The prevalence of diabetes is …
Coordinating behavior of hydrazone ligand bearing chromone moiety towards Cu (II) ions: Synthesis, spectral, density functional theory (DFT) calculations, antitumor …
EM Abdelrhman, BA El‐Shetary… - Applied …, 2021 - Wiley Online Library
A new hydrazone ligand (FCSH; HL) was successfully synthesized by the reaction of
salicylaldehyde hydrazone with 3‐formylchromone. Seven copper (II) hydrazone complexes …
salicylaldehyde hydrazone with 3‐formylchromone. Seven copper (II) hydrazone complexes …
Novel pharmacological approaches to the treatment of type 2 diabetes
EJ Verspohl, MC Michel - Pharmacological reviews, 2012 - Elsevier
The huge increase in type 2 diabetes is a burden worldwide. Many marketed compounds do
not address relevant aspects of the disease; they may already compensate for defects in …
not address relevant aspects of the disease; they may already compensate for defects in …
Synthesis, structural characterization, fluorescence, antimicrobial, antioxidant and DNA cleavage studies of Cu (II) complexes of formyl chromone Schiff bases
Cu (II) complexes have been synthesized from different Schiff bases, such as 3-((2-hydroxy
phenylimino) methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl) …
phenylimino) methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl) …
Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs
P Heneberg - Current medicinal chemistry, 2009 - ingentaconnect.com
Protein tyrosine phosphatases (PTPs) are considered to be involved in the etiology of
diabetes mellitus, neural diseases such as Alzheimer's and Parkinson's disease, regulation …
diabetes mellitus, neural diseases such as Alzheimer's and Parkinson's disease, regulation …