Introduction: The voltage-dependent potassium channel Kv1. 3 is mainly present in the
nervous and immune systems. In leukocytes, Kv1. 3 fine-tunes the activation and …

This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still
missing effective therapeutic strategies. Although manipulation of neuronal excitability has …

The olfactory system is a driver of feeding behavior, whereby olfactory acuity is modulated
by the metabolic state of the individual. The excitability of the major output neurons of the …

Background Ureases are metalloenzymes involved in defense mechanisms in plants. The
insecticidal activity of Canavalia ensiformis (jack bean) ureases relies partially on an internal …

The Kv1. 3 voltage-gated potassium channel regulates membrane potential and calcium
signaling in human effector memory T cells that are key mediators of autoimmune diseases …

The voltage-dependent potassium channel Kv1. 3 is a promising therapeutic target for the
treatment of autoimmune and chronic inflammatory disorders. Kv1. 3 blockers are effective in …

Abstract The KCa3. 1 channel (also known as the KCNN4, IK1, or SK4 channel) is an
intermediate-conductance calcium-activated potassium channel that regulates the …

The human voltage gated potassium channel Kv1. 5 that conducts the IKur current is a key
determinant of the atrial action potential. Its mutations have been linked to hereditary forms …

Venom‐derived ion channel inhibitors have strong channel selectivity, potency, and stability;
however, tracking delivery to their target can be challenging. Herein, we utilized luminescent …