Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Cellular senescence is an irreversible arrest of cell growth. Biochemical and morphological
changes occur during cellular senescence, including the formation of a unique cellular …

Mitochondrial DNA (mtDNA) is believed to be highly vulnerable to age-associated damage
and mutagenesis by reactive oxygen species (ROS). However, somatic mtDNA mutations …

Skeletal muscle aging is associated with a significant loss of skeletal muscle strength and
power (ie, dynapenia), muscle mass and quality of life, a phenomenon known as …

Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of
mitochondrial fission and fusion ensure metabolite and mitochondrial DNA mixing and …

It is now generally accepted that aging and eventual death of multicellular organisms is to a
large extent related to macromolecular damage by mitochondrially produced reactive …

Skeletal muscle–mass loss with age has severe health consequences, yet the molecular
basis of the loss remains obscure. Although mitochondrial DNA (mtDNA)–deletion mutations …

The somatic mutation theory of aging posits that the accumulation of mutations in the genetic
material of somatic cells as a function of time results in a decrease in cellular function. In …

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in
primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear …

Background Aging results in a progressive loss of skeletal muscle, a condition known as
sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal …