The classification of bone neoplasms composed of small round cells is experiencing a
transformation after the discovery of various gene fusion rearrangements that determine …

The cell surface molecule CD99 has gained interest because of its involvement in regulating
cell differentiation and adhesion/migration of immune and tumor cells. However, the …

Osteosarcoma, Ewing sarcoma and chondrosarcoma are rare diseases but the most
common primary tumors of bone. The genes directly involved in the sarcomagenesis, tumor …

Pediatric sarcomas are an extremely heterogeneous group of genetically distinct diseases.
Despite the increasing knowledge on their molecular makeup in recent years, true …

Identification of significant changes in urinary peptides may enable improved understanding
of molecular disease mechanisms. We aimed towards identifying urinary peptides …

Ewing sarcoma (ES) poses a significant therapeutic challenge due to the difficulty in
targeting its main oncodriver, EWS:: FLI1. We show that pharmacological targeting of the …

We report here that the autocrine signaling mediated by growth and differentiation factor 6
(GDF6), a member of the bone morphogenetic protein (BMP) family of cytokines, maintains …

Ewing sarcoma, the second most prevalent malignant bone tumor with potential occurrence
in soft tissues, exhibits a high level of aggressiveness, primarily afflicting children and …

Glioblastoma (GBM) is the most aggressive type of brain tumor, with an overall survival of 17
months under the current standard of care therapy. CD99, an over-expressed …

Ovarian cancer (OC) is the eighth most common type of cancer for women worldwide. The
current diagnostic and prognostic routine available for OC management either lack …